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Slay the Spire 2 Run Modifiers
All Star
Start with 5 colorless cards.
Big Game Hunter
Elite enemies swarm the Spire and drop better rewards.
Cursed Run
At the start of each Act, add a random Curse to your deck.
Deadly Events
Unknown rooms can now contain Elites, but are also more likely to contain Treasure rooms.
Draft
Choose 10 card rewards to replace your starting deck.
Flight
You may ignore paths when choosing the next room to travel to.
Hoarder
Whenever you add a card to your deck, add 2 additional copies. You can no longer remove cards from your deck at the Merchant.
Insanity
Start with a random deck of 30 cards.
Midas
Enemies drop 200% more gold, but you can no longer Smith at Rest Sites.
Murderous
You start each combat with 3 Strength. All enemies start combat with 3 Strength.
Night Terrors
Resting at Rest Sites heals all of your HP, but costs 5 Max HP.
Sealed Deck
Choose 10 out of 30 cards to replace your starting deck.
Specialized
Start with 5 copies of a single card.
Terminal
Whenever you enter a new room, lose 1 Max HP. Start each combat with 5 Plating.
Vintage
Normal enemies drop relics instead of cards.