Slime Boss is one of the three act 1 bosses in Slay the Spire. It is the third in the first-time order, after The Guardian and Hexaghost.

Slime Boss

NormalAscension
HP140150 from A9
Slam35 damage38 from A4
Goop Spray3 Slimed into your discard pile5 from A19

It always opens with Goop Spray, then Preparing, then Slam, and repeats.

The split

When Slime Boss drops to half its max HP or less (70, or 75 from A9), its next move is Split. It dies and is replaced by a Spike Slime (L) and an Acid Slime (L), each with Slime Boss's HP at the moment it split.

So every point of damage before the split counts twice: hitting Slime Boss from 71 down to 40 in one turn gives two slimes with 40 HP each instead of 70. Each large slime splits again into two medium slimes at half its own HP.

Poison on Slime Boss does not carry over to the slimes.

Silent cards that hit every slime

After the split you face two, then up to four slimes. Unupgraded values, with upgrades in brackets:

CardCostEffect
Dagger Spray14 (6) damage to all enemies twice
Die Die Die113 (17) damage to all enemies, Exhaust
All-Out Attack110 (14) damage to all enemies, discard 1 card at random
Crippling Cloud24 (7) Poison and 2 Weak to all enemies, Exhaust
Noxious Fumes12 (3) Poison to all enemies at the start of each turn
A Thousand Cuts21 (2) damage to all enemies whenever you play a card
Corpse Explosion26 (9) Poison; when that enemy dies, deal its max HP to all enemies
Piercing Wail1All enemies lose 6 (8) Strength this turn, Exhaust

Noxious Fumes and poison you apply after the split keep working on every slime; Poison applied to Slime Boss before the split is lost.

Slimed

Slimed is a status card that costs 1 energy to play and Exhausts. Goop Spray adds 3 to your discard pile every third turn until the split.

See act structure for the other act 1 bosses.